Endocrine Abstracts

Background and aims: The safety of thyroid surgery in terms of recurrent laryngeal nerve palsy and hypoparathyroidism was increasing in the last decade. In this study, we present a new method of tension-free thyroidectomy (TFT), which could be used to further decrease the complication rate after thyroidectomy.Patients and Methods: TFT is based on the medial approach to the recurrent laryngeal nerve (RLN) and the parathyroid glands after the division of i...

Introduction: Glucocorticoids are hormones that are used extensively in medicine for their anti-inflammatory and immunomodulatory effects. New onset diabetes mellitus is a frequent complication and is the result of an activation of glucocorticoid receptors which stimulate hepatic gluconeogenesis, adipose tissue lipolysis and increase the insulin resistance.Case presentation: We present a case of a 49-year-old Ukrainian female who in 2015 started having h...

The aim: To estimate secretory and proliferative activity of pituitary adenoma (isolated somatotropinoma (ST) and somatomammotropinoma (SMT).Subjects and methods: The study included 133 patients (total group: 45 male/88 female), aged 44.0±12.5 year old with acromegaly (95 – with ST and 38 – with SMT). There were estimated patient’s age, age of manifestation of acromegaly (agemanifest.), duration of period before diagnosis (...

Objective: The occurrence of cardiovascular disease (CVD) in patients suffering from type 2 diabetes is a widely discussed issue, less so in those with type 1 (T1DM). The purpose of this study was to evaluate the frequency of these complications as well as certain risk factors that they are associated with.Material and methods: We conducted a retrospective observational study by analyzing data from the observation charts of 106 patients evaluated in our ...

Introduction: Endocrinopathies are rare causes of erectile dysfunction and previously cases of hyperprolactinaemia and pituitary adenomas have been reported.Case report: We present the clinical case of a 27-year old male, married for 4 years with no children, presented with possible infertility and erectile dysfunction which was previously interpreted as caused by a poor social and psychological situation in the family. After additional endocrinological ...

Introduction: Thyroid dysfunction affect up to 5% of pregnant women and hypothyroidism complicates up to 3% of pregnancies, of which 0.3–0.5% is diagnosed as overt, 2.0–2.5% as subclinical hypothyroidism. Obesity in pregnant women may further contribute to the development of hypothyroidism and adversely affect the pregnancy. The aim of the study was to assess the risk of hypothyroidism in overweight and obese pregnant women on the basis of concentrations of TSH, free...

Introduction: Rapid-acting insulins is widely used in the treatment of either type 1 diabetes mellitus, or type 2 diabetes mellitus. A mealtime injection of rapid-acting insulin, such as insulin aspart, allow the diabetic patients to control the levels of post-prandial glucose. The clinical development plan of the insulin biosimilarsusually contains pharmacology studies to evaluate pharmacokinetics (PK), pharmacodynamics (PD) and clinical safety of the investigational products...

Objective: Diabetic foot complications are a main cause for hospital admissions and spending for patients suffering from T1DM or T2DM. The purpose of this study was to identify and compare possible risk factors for patients suffering from such issues.Methods: We conducted a retrospective observational study analyzing data from observation charts of 324 patients, diagnosed with T1DM or T2DM as well as various foot issues, evaluated between January 2015 &#...

Objective: Postoperative nausea and vomiting is common after general anaesthesia and is reported by ~20–25% of all patients. The standard prophylaxis at the authors department is a single treatment of 4 mg of dexamethasone before initiating anesthesia. Dexamethasone is known to suppress ACTH and cortisol levels. The objective was to find out whether the standard PONV-prophylaxis of 4 mg of dexamethasone has an effect on postoperative levels of cortisol in patients undergo...

Introduction: Some metabolic diseases, including type 1 (T1DM) and type 2 (T2DM) diabetes mellitus have an influence on bone homeostasis. These facts are of great socio-medical impact, since currently the DM2 and osteoporosis are considered public health problems.Objectives: (1) Determine the relationship between markers of bone metabolism and insulin resistance in postmenopausal women with and without T2DM.(2) Compare the bone min...